Molecular Interactions between Kv4.3 and DPP6 - The Biochemical Anatomy of Idiopathic Ventricular Fibrillation

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Founder mutations in the Netherlands: familial idiopathic ventricular fibrillation and DPP6

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Idiopathic Ventricular Fibrillation

Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) are disastrous outcomes of various predominant cardiac diseases. The leading cause of SCA and SCD is coronary artery disease. However, SCA/SCD in young patients is mainly caused by congenital disorders of primary arrhythmic or structural origin. SCD is defined as death from an unexpected circulatory arrest, usually because of a cardiac ...

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[Idiopathic ventricular fibrillation].

Idiopathic ventricular fibrillation is defined as cardiac arrest in the absence of structural heart disease and other identifiable causes of ventricular fibrillation. It occurs in 1% to 9% of survivors of out-of-hospital cardiac arrest. The mean age of these patients is 35 to 40 years, and 70% to 75% are male. The pathogenesis is unknown; psychosocial factors may play a role. Baseline clinical ...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2017

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2016.11.1016